“Takes an awful lot off of the win, to be honest with you,” Coughlin said.
The injury reportedly  will be season-ending for Brown.
Brown is not ruling himself out. He tweeted early Monday  that his season wasn’t necessarily over.
Brown has rushed 73 times for 385 yards and eight touchdowns this season.
The Giants now will rely on Ahmad Bradshaw  and rookie David Wilson to step up and fill Brown’s role.
“I feel bad for Andre, he’s my little brother,” Bradshaw said. “It’s heartbreaking for me just to see him so down. When I was a rookie I told David, [Derrick] Ward broke his fibula and I had to step in and be a big part of our offense. That’s what I expect from David and I told him to get right and get ready for the following weeks to come.”
Wilson said he is ready to help the Giants, who sit atop the NFC East.
“Dre played a big role in our offense running the ball, I’m definitely going to have to step up when my number is called and be prepared,” Wilson said.